So I cheated a little, because I’m at a table right now, so I didn’t visualise the table just the ball on the table. It was about tennis size, but no texture, kind of light blue shading into lilac. The person pushing it was really just a hand.

So sounds like the only work I did was imagining the ball. I wouldn’t say I knew in advance, and I wouldn’t say I chose what it looked like. It just appeared and it was light blue.

Edit: the ball started rolling when pushed, but not long enough for me to know whether it fell off the table or not. But the rolling was just a concept. I can visualise things, but I can’t visualise motion. Which I only discovered recently.

I think it’s a modern word, as for example it doesn’t figure in Merriam-Webster. But it was created in a classical way, i.e. from Greek words meaning “stumble” and “talking”.

Something I learnt recently and which is rampant on gay social apps: sphallolalia - flirting that doesn’t lead to meeting irl.

If you travel a lot, Toilet finder.

Edit: and not an app, but a website: Pairdrop - really useful for cross-platform file sharing, especially when you just need to email to colleagues something you snapped with your personal phone, but yoe have overly tight IT systems in place at work that stop you from connecting your personal phone to your email or OneDrive.

2009? It will expire in 5 years and we’ll be inundated with devices that require you to get up from your seat and yell out the name of the brand to end an ad ☹️

I’ve just asked Gemini about cheese that slides off pizza, it didn’t recommend glue.

What does ‘rolling encryption’ mean (if it’s possible to ELI15).

What is your 6 year old laptop’s make?

I actually can’t complain. It’s not perfect, but I’m far from being as outraged as the OP. I used to love SwiftKey, it was amazing with text prediction, even when you had two languages on at the same time (I’m bilingual, so it was really handy). Since Microsoft bought it, it started going downhill and when I found that I can’t just transfer my settings when I get a new phone, I switched to Gboard. Again, not perfect, but not terrible either. I will try out some of the recommendation from this thread though.

Could someone ELI5 (if possible) what passkeys actually are?

Of course I noticed! It’s really annoying for a creature of habit like me :(

That was my thought when I started reading the piece. “Are we just going to call it XFT?”

Thanks for explaining this. I’m a childless guy living in the UK in a big city, close to many big markets and specialty stores, so I guess my experience is totally different than what you’re describing and you gave a few pretty good reasons why there’s such a gap in how much the convenience of Prime is worth for someone like you and someone like me. I guess the article just isn’t aimed at people like me.

Wow, never thought I’d see a headline like this. I’ve never had Amazon prime except for the free month trial. I had no idea it was such a problem for others that there are articles written about it.

is overhearing and joining random conversations a business plan?

That really made me laugh. No, of course it’s not a business plan. I was just trying to make a point that there are benefits to people being together in the office.

This is probably going to be an unpopular comment, but I wanted to present the view in favour of what I call WFW (working from work). I’m sure it’s always going to be different for specific cases, but I do see benefits of WFW. We have an open plan office and a lot of casual conversations between us turn into serious conversations about projects and sometimes they have important outputs. Sometimes you overhear a conversation that you realise you know something about and you make a valuable contribution to it. None of this happens when people are WingFH. I’m lucky enough that my only line report is a hard working person, so I let them WFH probably a bit more than other managers let their reports, but I still like when they are WFW because of the contributions that they make to those conversations I mentioned above.

I’m an introvert, so I totally get the argument of being able to focus better when you’re not surrounded by people and their conversations, but at the same time I honestly noticed that my productivity decreases when I WFH. I’m sufficiently honest with myself to notice that and feel bad about it and this is actually the main reason why I do commute for an hour every day just to WFW, even though our company policy says that we can WFH 3 days a week and my job is 95% desk based.

I think it’s often has to considered for individual cases because as I said, my report does 110% whether they WFH or WFW, but I know from other managers that some of their reports really stuttered and stumbled when they were asked “so you WedFH yesterday, what did you do exactly?”

I’m not trying to say “everyone should stop WFH”, but it seems to me that most of the comments in this post are aligning with “just let your employees WFH!” and I wanted to present the other point of view, from the perspective of a non-senior manager who also has some non managerial responsibilities himself.

Of course it needs to be controlled and regulated. Like any other drugs. One of the reasons drugs are expensive is because there is so many regulatory hurdles that drug makes have to deal with before they can touch a patient.

I get your hypothetical, but it has two shortcomings. Firstly, training the immune system against cancer mutations is fairly easy, because the mutations are not present during the process of T and B cell maturation, so in the population of circulating naive T and B cells in a patient, there are likely to exist ones that are going to recognise the cancer antigen. Whatever proteins drive the dark pigmentation of skin or green eye colour will be used to drive the negative selection of T and B cells in the person with dark skin or brown eyes. And so, even if you administer a “vaccine” encoding these proteins, their immune systems will not be able to mount a response against them.

Secondly, what about the practicalities. Say you made the anti-green eye vaccine - how do you administer it to people? I’m assuming we’re not talking about some dystopian future where forcing people to receive injections that contain biologicals killing them is legal. It’s not the kind of “vaccine” that you could just spread in the air or add to drinking water for it to take effect.

I think the first point to make is that this is not really the patient’s own genetic information, but that of their cancer, something they desperately want to get rid of. And the second point is that to my knowledge, there is no county on earth, where taking part in a clinical trial would not require the patient’s consent, which is to say, all people in the study were informed that the genetic sequences of their cancers will be analysed and used to generate a vaccine.

As for the potential to become a weapon, you would have to elaborate, because I really don’t see how the Moderna vaccine strategy could be weaponised.

In general, mutations can happen anywhere on any gene, so every patient’s cancer will have its unique signature of mutations. However, like in the evolution of organisms by natural selection, most random mutations will have a detrimental effect and the cells carrying it will die. Some of the mutations will be neutral and despite the change in the amino acid, the cells harbouring it won’t survive better or worse than cells that don’t have it. But a few mutations will make the cancer cells proliferate faster or evade the immune system better, which will lead to these cells surviving and ultimately overtaking the population of the cancer cells. The latter mutations often happen in the same places on the same genes, and in melanoma for example, in as many as 41% of cases the 600th amino acid in a protein called BRAF mutates from valine to alanine (so the code for that mutation is “BRAF V600E”), and BRAF is only one example of such genes that commonly mutate in the same position.

So to answer your question - I don’t know Moderna’s exact protocol, but my guess is that the tailored vaccine will contain a mixture of these commonly occurring mutations and some mutations that are unique to the patient.

I think you’re amazing. Having faced such tremendous adversities at such young age, you still think that the main message you need to share is that life is fucking incredible.

I’m not a blogger or anything, so I’m sorry for posting a comment without any answers to the question in the title. But if the outlet you choose ends up being publicly available, please share the link. I would love to read whatever you think is worth writing down.