I’ve never daily driven it as my main machine but I’ve used it as an auxiliary driver for a more high-security machine. Afaik things like gaming are sort of a no-go on Qubes still.
Qubes does not just do sandboxing. It runs all user programs in VMs, which adds non-negligible overhead and makes it an unsuitable OS for many more lightweight systems like laptops. And even if your PC can run Qubes without issue, you may not want that additional overhead if you want to do anything computationally intensive.










I mean, I only have one GPU, so if passthrough is required then that does make gaming more inaccessible.