I did this this year for wildfire smoke, and it works great. Having said that, it is not quiet and the way I was using it was to run it at full blast for an hour, then leave it off for most the day.

If you wanted an always-on solution, I think I’d actually suggest a commercial air purifier.

“Chaser” because we live out in the country and use it to pick up our dogs who sometimes wander off and we have to go retrieve. Also, because it’s a Chevy. It’s Chevy Chase_r_.