I feel like on mobile 16px/1rem is perfect, but on desktop it may be too small.
There is a discussion on Hacker News, but feel free to comment here as well.
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no
No, make everything relative to 1rem and test with different zoom levels. There is nothing more annoying than a site that does not change paragraph width when you zoom in. Also, I am using custom font sizes / zoom levels because of reading difficulties, having to adjust settings is annoying.